Studies on the Effects of Injected Amount of I<sup>131</sup> in Uptake and Release Rate by Thyroid in Guinea Pigs 1. On the Influence of Injected Amount of Redioiodine-<sup>131</sup> in Uptake and Release Rate by Thyroid in Male Guinea Pigs

Chung, Yung Chai; Shim, Sang Chil; Lee, Heung Shik

Korean Journal of Veterinary Research 1966;6(1):24-30.

Studies on the Effects of Injected Amount of I¹³¹ in Uptake and Release Rate by Thyroid in Guinea Pigs 1. On the Influence of Injected Amount of Redioiodine-¹³¹ in Uptake and Release Rate by Thyroid in Male Guinea Pigs

Yung Chai Chung¹, Sang Chil Shim², Heung Shik Lee²

¹College of Agriculture, Choong Nam University
²College of agriculture, Seoul National University

방사성옥도(放射性沃度)(I¹³¹)의 주입량(注入量)이 기니픽 갑상선(甲狀腺)에의 섭취(攝取) 및 방출률(放出率)에 미치는 영향(影響)에 관(關)한 연구(硏究) 제(第)1보(報) 방사성옥도(放射性沃度)(I¹³¹)의 주입량(注入量)이 웅(雄)기니픽 갑상선(甲狀腺)에서의 섭취(攝取) 및 방출률(放出率)에 미치는 영향(影響)

정영채¹, 심상칠², 이흥식²

¹충남대학교 농과대학
²서울대학교 농과대학

Abstract

In order to observe the effect of the injected radioactive iodine-$I^{131}$ on the uptake in thyroid of normal male guinea pigs and P.B.$I^{131}$ conversion ratio of $I^{131}$ in serum, 24 matured male guinea pigs were divided in 4 groups and $35{mu}c$, $70{mu}c$, $140{mu}c$ and $280{mu}c$ per kg of body weight respectively were injected subcutaneously. 1. The uptake rates of radioactveiodine-$I^{131}$ by external counts of thyroidal uptake reached the maximum level of uptake in 24 hours after injection. 2. As the injected amount increases, the uptake rates of maximum levels and release rate were increased. 3. Uptake rate in the removed thyroid have shown no statistical in the $35{mu}c$ and $70{mu}c$ groups of injected guinea pigs. 4. There was no statistical significance in $140{mu}c$ and $280{mu}c$ groups of injected guinea pigs. 5. P.B.$I^{131}$ conversion ratio of $I^{131}$ in serum was not in proportion to injected amounts: 61.0%(35), 70.2%(70), 75.3%(140) and 64.8%(280).