Mammary and renal excretion of sulphamethomidine in cows

Lee, Jang-nag; Kjaersgaard, Per

Korean Journal of Veterinary Research 1967;7(2):51-55.

¹Dept. of Veterinary Medicine, College of Agriculture Seoul National University
²Dept. of Pharmacology and Toxicology, Royal Veterinary and Agricultural College

Sulphamethomidine의 젖소에 있어서의 유선과 신장을 통한 배출

이장낙¹, ²

¹서울대학교 농과대학
²덴마크왕립수의과 농과대학

Abstract

The mammary excretion of suphamethomidine after intravenous and/or oral administration was investigated in cow. The results show that sulphamethomidine is bound to plasma proteins to a great extent (80~90%). Ay a dosage of 60 mg./kg. maximal concenration in plasma of this sulphonamide was reached 7-10 hours after oral dosing. The sulphonamide concentration in plasma slowly declined after both oral and intravenous administration (fig. 1, 2, and 3) The concentration of sulphonamide in milk was very low and the excretion was completed in 7 days after a single oral dose and 5 days after intravenous injection while in the case of blood plasma it was 11 and 7 days, respectively. In addition, the renal excretion of sulphamethomidine was investigated while under continuous intravenous intravenous infusion. The excretion ratios varies according to self depression (table. 1). Blockade of the tubular secretion with diodone lowered the excretion of sulphamethomidine. It is concluded that the renal excretion of sulphamethomidine in cows occurs by filtration by slight tubular secretion and also by a high rate of back diffusion.