Histopathological Observation and Effect of DL-α-Tocopherol on Hyperbaric Oxygen Toxicity

Lee, Won Chang; Yoon, Wha Joong

Korean Journal of Veterinary Research 1975;15(1):47-50.

Won Chang Lee, Wha Joong Yoon

Department of Veterinary Medicine, College of Animal Husbandry Kon Kuk University

고압산소(高壓酸素)가 폐조직(肺組織)에 미치는 영향(影響)과 DL-α-Tocopherol의 내성효과(耐性效果)에 관(關)한 연구(硏究)

이원창, 윤화중

건국대학교 축산대학 수의학과

Abstract

Experimental studies were performed to observe the effect of exposure to 100% oxygen in 2 atmospheres on the lung tissue of rats, and to examine the resistant effect of DL-${alpha}$-tocopherol. The following results were made through this experiment: 1. Half-lethal time by oxygen poisoning was longer in tocopherol treated group than not treated group. 2. Ratio of lung weight to body weight was significantly higher in fatal group within half-lethal time than survival group (p<0.01). 3. Histopathological changes of the lung by oxygen toxicity were vascular congestion, pulmonary edema, hemorrhage and emphysematous change. The degree of changes were rather marked in experimental group than tocopherol untreated group. Those were regard as the changes being occurred during tolerance process by prolonging half-lethal time.