Ultrastructural Alterations of Rabbit Liver after Overdose of Nitrate

Kim, Soon Bok; Lee, Cha Soo

Korean Journal of Veterinary Research 1976;16(2):141-150.

¹Institute of Veterinary Research, Office of Rural Development
²Department of Veterinary Medicine, College of Agriculture, Gyeongbug National University

질산염과잉투여(窒酸鹽過剩投與)에 의(依)한 간장(肝臟)의 변화(變化)에 관한 전자현미경적연구(電子顯微鏡的硏究)

김순복¹, 이차수²

¹농촌진흥청 가축위생연구소
²경북대학교 농과대학 수의학과

Abstract

In order to know the morphological changes of liver in nitrate poisoning, the ultrastructural studies were carried out on the rabbit liver after potassium nitrate was administered orally at lethal dose, in single treatment, as acute case and at two different levels. 1.0 and 0.5g/kg of body weight daily for 43 and 60 days as chronic case, respectively, The results were summarized as followings: 1. In the hepatic cells of acute case, mitochondria were swollen, disappearance of cristae and variable in shape. Dilatation of rough endoplasmic reticulum and vacuoles containing degenerated cell organells were observed. Glyogen particles were decreased in number. Degenerated Kupffer cells were often seen in acute case. 2. In the hepatic cells of chronic case, there were increase of smooth endoplasmic reticulum, marked enlargement of rough endcplasmic reticulum, detachment of membrane bound ribosome and some rough endoplasmic reticulum changed into smooth endoplasmic reticulum. Secondary lysosome, abundant glycogen paricles and myelin-figure structures were also observed in the cytoplasm of the hepatic cells. The endothelial cells were proliferated in the area of the necrotic cells.