Protection Mechanism of Infection Against Tyzzer's Disease

Lee, Yong Soon; Lee, Jang Nak

Korean Journal of Veterinary Research 1980;20(1):33-38.

Yong Soon Lee, Jang Nak Lee

College of Veterinary Medicine, Seoul National University

마우스에 있어서의 Tyzzer병(病) 감염방어기구(感染防禦機構)

이영순, 이장락

서울대학교 수의과대학

Abstract

1. In adult ICR-SLC mice, significant increase in the occurrence of the Tyzzer's disease was noted when the reticuloendothelial system was blockaded with the carbon particles. The most suitable bloakading time was 2 hours before inoculating Tyzzer's organisms, the route was intraperitoneal and the dose was 3mg/body. 2. Survival rate of the experimental group ICR-SLC suckling mice receiving BCG ($3{ imes}10^8$) 6 days prior to intraperitoneal inoculation of Tyzzer's organisms was 80 percent, but the control group was 17%. 3. In comparing the survival rate of the nude/nude mice with the nude/+ mice, the former congenitally thymus deficient mice are 11 percent, but the latter are 67 percent.