| Effects of Over-dosed Lead and its Interaction with Iron, Copper, Zinc or Protein Supplement in Chicks |
|
Jun-hong Park, Chun-su Kim |
|
Korea Advanced Institute of Science and Technology |
| 초생추에서의 납의 독성과 철·구리·아연 및 단백질과의 상호작용 |
|
박전홍, 김춘수 |
|
한국과학기술원 |
|
|
| Abstract |
|
The protective effects of high levels of dietary iron, copper, zinc or protein on lead toxicity were studied In chicks. Growth retardation, reduction of feed intake, anemia and accumulation of lead in the bone and kidney were observed in chicks fed a diet containing 500mg lead as chloride per kg of feed for 42 days. Early changes due to ingested lead were inhibition of red blood cell ${delta}$-aminolevulinic acid dehydrase at all doses and no effect of iron, copper, zinc or protein addition were observed. Tibia lead accumulation was reduced in chicks receiving additional dietary iron or zinc compared to the lead only group but increased in chicks given supplementary protein. Decreased body weight gain was overcome by supplementary zinc or protein in chicks fed lead but not by supplementary iron. Overall the results of this study show that lead poisoning can be partly reduced by providing supplementary iron, zinc or protein, but the interaction of these element remained to be elucidated. |
|
PDF Links
Full text via DOI
Download Citation
