| The radioprotective effects of Bu-Zhong-Yi-Qi-Tang and its major ingredients in irradiated mice |
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Sung-ho Kim1, Heon Oh1, Se-ra Kim1, Sung-kee Jo2, Myung-woo Byun2, Dong-ho Shin1 |
1College of Veterinary Medicine, Chonnam National University
2Food Irradiation Team, KAERI |
| 방사선 피폭 마우스에서 보중익기탕 및 구성단미의 효과 |
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김성호1, 오헌1, 김세라1, 조성기2, 변명우2, 신동호1 |
1전남대학교 수의과대학
2한국원자력연구소 방사선 식품공학팀 |
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| Abstract |
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We performed this study to determine the effect of Bu-Zhong-Yi-Qi-Tang, as a prescription of traditional Oriental medicine, and its major ingredients on jejunal crypt survival, endogenous spleen colony formation, apopotosis in jejunal crypt cells, lethality and hematological change of mice irradiated with high and low dose of Y-radiation. Bu-Zhong-Yi-Qi-Tang administration before irradiation protected the jejunal crypts (p<0.0001), increased the formation of endogenous spleen colony (p<0.05) and reduced the frequency of radiation-induced apoptosis (p<0.05). The survival rate and mean survival time of the groups treated with Bu-Zhong-Yi-Qi-Tang within 30 days after the treatment were far better than the irradiation control group. In the experiment on the effect of ingredients of Bu-Zhong-Yi-Qi-Tang, the result indicated that the extract of Rensan (Panax ginseng), Danggui (Angelica sinensis), Shengma (Cimicifuga heracleifolia) and Chaihu (Bupleurum falcatnosa) might have a major radioprotective effect. Although the mechanisms of this inhibitory effect remain to be elucidated, these results indicated that BU-Zhong-Yi-Qi-Tang might be a useful radioprotector, especially since it is a relatively nontoxic natural product. Further studies are needed to characterize better the protective nature of Bu-Zhong-Yi-Qi-Tang extract and its ingredients. |
| Key Words:
radiation, Bu-Zhong-Yi-Qi-Tang, mouse, radioprotector |
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