Application of oral cyclosporine in a dog with atopic dermatitis

Park, Seong-jun

Korean Journal of Veterinary Research 2005;45(3):439-444.

Seong-jun Park

College of Veterinary Medicine, Chungnam National Unviersity

개의 아토피성 피부염에 대한 cyclosporine의 경구 요법

박성준

충남대학교 수의과대학

Abstract

A 7.1 kg, seven-year old, castrated male, Shih-Tzu with severe pruritus, chronic otitis externa and Malassezia infection was referred to Veterinary Medical Teaching Hospital of Chungnam National University. In local animal hospital, steroid therapy was used to treat uncontrollable pruritus, but the clinical signs were recurrent when steroid therapy was discontinued. On physical examination, generalized alopecia, erythema, papules, severe crust and diffuse lichenification were presented. Tape strip test of skin lesions revealed cocci and Malassezia infections. Based on the result of history, clinical signs and examination described above, canine atopic dermatitis with secondary superficial pyoderma and Malassezia dermatitis was diagnosed. Oral challenge with cyclosporine and antibiotics had good results in clinical signs. Clinical sign scores were evaluated by investigator with CADESI at 2weeks, 4weeks, 6weeks, 8weeks and 10weeks after cyclosporine administration. And in the result of comparing of allergen-specific IgE value, the level of allergen-specific IgE to general causative allergen after 10 weeks of cyclosporine therapy was higher than that before cyclosporine therapy.

Key Words: atopic dermatitis, pruritus, cyclosporine, allergen specific IgE test