| Protective effects and immunogenicity of Salmonella Enteritidis killed vaccine strains selected from virulent Salmonella Enteritidis isolates |
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Zheng-Wu Kang1, Ho-Keun Won2, Eun-Hee Kim2, Yun-Hee Noh2, Hwan-Won Choi2, Tae-Wook Hahn1 |
1College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University
2ChoongAng Vaccine Laboratories |
| Salmonella Enteritidis 분리주에서의 선발된 불활화 백신균주의 방어효과 및 면역원성 |
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강정무1, 원호근2, 김은희2, 노윤희2, 최환원2, 한태욱1 |
1강원대학교 수의과대학, 동물의학종합연구소
2중앙백신연구소 |
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| Abstract |
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Salmonella Enteritidis (SE) has been a major causative agent of food-borne human disease due to consumption of contaminated eggs and poultry meat. To prevent SE infection in poultry, and therefore minimize human infections, vaccination with either killed or live SE vaccine is suggested. We evaluated a newly developed killed bacterin using a representative SE isolate in Korea. Among pool of SE isolates, two highly virulent isolates (the one isolate from chicken, the other from human) were selected by measuring mortality in mouse and chickens administered. The chickens were injected intramuscularly with killed vaccine and were challenged with highly virulent SE strain 3 week after vaccination. The recovered colony count (cfu/g) of spleen and cecal content in the vaccinated groups was reduced compared with those of the unvaccinated control group. The antibody level in the vaccinated groups was higher at 3 week post vaccination. These results indicate that vaccination with killed vaccine was effective in preventing the infection of virulent SE. Further study for a large number of layers should be needed for the effect of egg production, SE shedding in feces, persistence of antibody level. |
| Key Words:
antibody response, immunogenicity, killed vaccine, protective effect, Salmonella Enteritidis |
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