Clinical trial of diltiazem on dystrophic calcinosis cutis in a dog

Cho, Na-Young; Cho, Dae-Hee; Choi, Ho-Jung; Jeong, Seong-Mok; Lee, Young-Won; Park, Seong-Jun

doi:2013.53.3.181

Korean J Vet Res > Volume 53(3); 2013 > Article

Case report

Korean Journal of Veterinary Research 2013;53(3):181-184.
DOI: https://doi.org/10.14405/kjvr.2013.53.3.181 Published online September 26, 2013.

Clinical trial of diltiazem on dystrophic calcinosis cutis in a dog

Na-Young Cho, Dae-Hee Cho, Ho-Jung Choi, Seong-Mok Jeong, Young-Won Lee, Seong-Jun Park

College of Veterinary Medicine Research Institute of Veterinary Medicine, Chungnam National University

개의 이영양성 피부 석회증에 대한 diltiazem의 적용 1례

조나영, 조대희, 최호정, 정성목, 이영원, 박성준

충남대학교 수의과대학 동물의과학연구소

Abstract

Dystrophic calcinosis cutis associated with spontaneous hyperadrenocorticism was diagnosed in a 8-year-old female Chihuahua dog with erythematous, erosive, numerous papules, plaques, and crusts on the bilateral trunk, and inguinal region. Serum biochemical abnormalities included increases in alkaline phosphatase (ALP), alanine aminotransferase (ALT), gamma-glutamyl transpeptidase (GGT), and cholesterol. Radiographs showed mild hepatomegaly and subcutaneous lobulated calcific deposits. Histopathologic examination demonstrated diffuse deposition of basophilic calcified material in the dermis. Von Kossa's stain confirmed calcium deposition. Therapy with diltiazem was useful in resolving calcinosis.

Key Words: diltiazem, dog, dystrophic calcinosis cutis, hyperadrenocorticism