| Clinico-pathological studies on the experimental lead poisoning in goats I. Clinical observations(Clinical, hematological and urinary findings) |
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Oh-deog Kwon1, Hyun-beom Lee2, Joo-mook Lee1, Joon-seok Chae1 |
1College of Veterinary Medicine, Chonbuk National University
2College of Veterinary Medicine, Kyungpook National University |
| 산양의 실험적 납중독에 관한 임상병리학적 관찰 I. 임상학적 관찰(증상, 혈액, 뇨) |
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권오덕1, 이현범2, 이주묵1, 채준석1 |
1전북대학교 농과대학
2경북대학교 수의과대학 |
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| Abstract |
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Present experiments were undertaken in order to clarify the clinico-pathological characteristics of lead poisoning in goats. Twenty goats were divided into three experimental groups(A, B and C) and a control(D). The three experimental groups received diets contaminated artificially with 10(A group), 200(B group) and 1,000(C group) ${mu}g/$ of lead, for 70 days respectively. The control group received normal diets. Blood samples were collected 1 or 2 weeks interval and were examined for anemia(erythrocyte counts, hemoglobin concentrations and hematocrit values) and lead contents of erythrocyte and serum. Urine samples collected similarly with blood were examined for delta-aminolevulinic acid and lead content. Collected samples were analyzed for lead content by atomic absorption spectrophotometry. From these experiments following results were obtained : In group B and C, marked decreases in body weight and feed intake, and diarrhea were observed from the $30^{th}$ day of experimental periods. The B and C groups showed pronounced anemia(decrease in erythrocyte count, hemoglobin concentration and hematocrit value) from the $21^{st}$ or $42^{nd}$ day. In group B and C, the lead content of erythrocytes was increased significantly from the $28^{th}$ or $14^{th}$ day. The lead content of serum was increased significantly from the $42^{nd}$ or $14^{th}$ day in B and C groups. The lead content of urine was increased significantly from the first day in both B and C groups. The urinary delta-aminolevulinic acid content was increased significantly from $14^{th}$ day in both B and C groups. |
| Key Words:
goat, lead, blood, urine, delta-aminolevulinic acid |
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