Korean Journal of Veterinary Research 2003;43(2):203-210.
Pharmacokinetics and Tissue Distribution of Recombinant Bovine Somatotropin after Subcutaneous Administarion in Male and Female Rats
Byung-kwon Park1, Seung-chun Park2, Hyo-in Yun1
1College of Veterinary Medicine, Chungnam National University
2College of Veterinary Medicine, Kyungpook National University
Recombinant Bovine Somatotropin의 피하주사 후 Male과 Female Rat에서 약물동태 및 조직분포
박병권1, 박승춘2, 윤효인1
1충남대학교 수의과대학
2경북대학교 수의과대학
Abstract
The purpose of this study is to investigate the pharmacokinetics and tissue distribution of recombinant bovine somatotropin (rBST) after subcutaneous adminstration of $^{125}I-rBST$ in male and female rats. A solid state conjugation (Iodo-bead$^{(R)}$) method was confirmed useful for producing $^{125}I-rBST$ because the administration of the conjugated form enabled enough to determine time- concentration relationships of rBST in rats. Subcuatenous administrations showed sex differences that female ($t_{1/2,kc}$, 2.87 h) revealed rapid elimination as compared to male ($t_{1/2,ke}$, 4.81 h), with the absorption ($t_{1/2,ka}$ in male being 0.3 h and that in female 0.75 h) in the reverse order. For subcutaneous administration of rBST in male rats, the liver was the highest in amount, followed by kidney, testes, muscle, and stomach, at the slaughtering tame of 1, 6, 12 and 24 h. But the testes was the highest at the 48 h slaughtered animals, followed by liver, kidney, stomach, and muscle. In slaughtered females at 1, 6, and 12 h after the administration of rBST, the liver was the highest, followed by ovary, kidney, small intestine, and stomach. At 24 and 48 h slaughtered female rats, the ovary was the highest, the liver the second, and the kidney the third.
Key Words: Recombinant bovine somatotropin, rats, pharmacokinetics, tissue distribution, conjugation


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