Korean Journal of Veterinary Research 2010;50(3):187-195.
Biological activities and single oral dose toxicity in rat of fermented Rhus verniciflua extract
Myung-Jin Choi1, Seung-Jin Lee1, Seung-Hee Jang1, Md. Ahsanur Reza1, Joo-Heon Hong2, Hee-Kyoun Jung3, Seung-Chun Park1
1College of Veterinary Medicine, Kyungpook National University
2Department of Food Science and Technology, Catholic University of Daegu
3Bio Industry Center, Daegu Technopark
발효 옻 추출물의 생리활성 및 단회 경구 투여 독성시험
최명진1, 이승진1, 장승희1, 1, 홍주헌2, 정희경3, 박승춘1
1경북대학교 수의과대학
2대구가톨릭대학교 외식식품산업학부
3대구테크노파크 바이오산업지원센터
In this study, we investigated the biological activities such as anti-tumor, anti-oxidant and antiinflammatory activities as well as single oral dose toxicity of fermented Rhus verniciflua extract (FRVE). In order to examine anti-tumor activity of FRVE, the sarcoma 180 cells were treated with FRVE at various concentrations (0.03, 0.3, 3 and 30 mg/mL) in microtetrazolium (MTT) assay. In MTT assay, all the cells treated with FRVE at various concentrations have shown a significant difference compared with control (p < 0.05). In xanthine oxidase inhibition assay to examine the antioxidant activity, the xanthine oxidase inhibition rate of FRVE at 1.5 mg/mL and 15 mg/mL was $85{pm}15.01%$ and $99{pm}16.02%$, respectively. Nitric oxide production in RAW 264.7 cells showed that FRVE showed a significant anti-inflammation effect at 3 mg/mL (p < 0.05). In single oral dose toxicity study, no differences were observed between control and treated groups in clinical signs, body weight gains, feed and water consumptions. The results indicated that lethal dose 50 ($LD_{50}$) of FRVE was found to be higher than 5,000 mg/kg in this experiment. From the above results, we may suggest that FRVE might have useful as a material for functional food and/or animal pharmaceutics.
Key Words: anti-inflammation, anti-oxidant, anti-tumor, Rhus verniciflua, single-dose toxicity
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