Korean Journal of Veterinary Research 2010;50(4):259-264.
Histopathological effect of experimental feeding of melamine and cyanuric acid in kidney of crucian carp (Carassius carassius)
Seong-Jin Wang, Gang-Joon Heo
College of Veterinary Medicine, Chungbuk National University
Melamine과 cyanuric acid의 혼합투여가 붕어(Carassius carassius)의 신장에 미치는 조직병리학적 영향
왕성진, 허강준
충북대학교 수의과대학
Melamine is an organic base and a trimer of cyanamide which contains 66% nitrogen by mass, but it was sometimes illegally added to food products in order to enhance the apparent protein content for the bigger profit. Many Chinese infants and pet animals fed melamine-containing formulas suffered acute kidney failure with renal crystal formation. Fish feeds were also recently found to be contaminated with melamine. This experiment has been designed to determine whether renal crystals can be experimentally induced in crucian carp (Carassius carassius) fed melamine and cyanuric acid (each at 400 mg/kg/day for 3 days) in combination, and to compare experimentally induced crystals with those from pet animals with triazine related renal failure. The results showed that all fish developed gold brown renal crystals arranged in radial spherulites in the renal tubules, similar to those detected in the pet animals.
Key Words: crucian carp, cyanuric acid, melamine, renal crystal, renal failure

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