Korean J Vet Res > Volume 55(4); 2015 > Article
Korean Journal of Veterinary Research 2015;55(4):247-252.
DOI: https://doi.org/10.14405/kjvr.2015.55.4.247    Published online December 31, 2015.
A novel biomarker of exercise-induced stress in horses
Seungwoo Lee, Dayoung Oh, Myung-Chul Kim, Yongbaek Kim, Doug-Young Ryu
College of Veterinary Medicine, BK21plus Program for Creative Veterinary Science Research, and Research Institute for Veterinary Science, Seoul National University
말의 운동 스트레스에 관한 새로운 생물지표
이승우, 오다영, 김명철, 김용백, 류덕영
서울대학교 수의과대학, BK21수의과학연구인력양성사업단, 수의과학연구소
Exercise is one of the most common stressors in horses. Although various physiological parameters such as cortisol respond to exercise, there is no reliable parameter for the measurement of exercise-induced stress in sport horses. This study was performed to discover a new biomarker with high sensitivity for exercise-induced stress. The expression of fos mRNA was increased more than 10-fold in horse blood samples collected after an hour of exercise, as compared with before the exercise. The plasma cortisol levels were also increased after the exercise, but only by about two-fold. The fos mRNA levels were well-correlated with plasma cortisol concentrations. These findings suggest that fos mRNA expression in blood may be useful for the measurement of exercise-induced stress in horses.
Key Words: biomarker, exercise, fos, horse, stress
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