Korean J Vet Res > Volume 57(1); 2017 > Article
Korean Journal of Veterinary Research 2017;57(1):59-61.
DOI: https://doi.org/10.14405/kjvr.2017.57.1.59    Published online April 27, 2017.
Fulminant multicentric osteosarcoma with systemic metastasis in a dog
Jeong-Ha Lee1, Du-Min Go1, Su-Hyung Lee1, Gwan-Gu Lee2, Min-Cheol Choi3, Hwa-Young Youn2, Dae-Yong Kim1
1Department of Veterinary Pathology and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University
2Department of Internal Medicine, College of Veterinary Medicine, Seoul National University
3Department of Diagnostic Imaging, College of Veterinary Medicine, Seoul National University
Abstract
A 15-year-old castrated mixed breed dog presented due to a 5-month history of cough and difficulty in ambulation. Necropsy showed multiple periosteal and intramedullary infiltrative masses in the appendicular skeleton. In addition, single and multiple neoplastic nodules were observed in several organs, including the lungs, liver, kidney, and heart. Microscopically, several skeletal neoplastic masses and nodules in the parenchymal organs revealed similar changes. The neoplastic cells were spindle- to polygonal-shaped with prominent osteoid production and occasional cartilaginous and bone formation. Based on the gross findings and histopathology results, the case was diagnosed as multicentric osteosarcoma with systemic metastases.
Key Words: dogs, metastasis, neoplasm, osteosarcoma


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