| Hangover relieving effect of Sanghwang mushroom mycelium cultured in germinated buckwheat |
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Yoo-Jin An1, Sung-Min Cho1, Min-Su Kim1, Hae-Hee Moon1, Dong-Soo Park2, Nam-Gen Jeon2, oungjae Lee1, Chang-Hoon Han1 |
1College of Veterinary Medicine, Jeju National University
2Jeju Sanghwang Co., Ltd. |
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| Abstract |
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The present study was performed to evaluate the hangover relieving effect of germinated buckwheat (GB) and Sanghwang mushroom mycelium cultured in GB (SGB). Both GB and SGB showed 1,1-diphenyl-2-picrylhydrazyl radical scavenging activities and significantly increased (p < 0.001) aldehyde dehydrogenase (ALDH) activities; up to 140% increase at concentrations of $16{mu}L/mL$. Locomotor activity test results from alcohol-SGB and alcohol-GB groups showed improved motor activities over that of the alcohol-water group at 90 min post-administration. Both alcohol-GB and alcohol-SGB groups had significantly reduced (p < 0.001) alcohol ($40.02{pm}33.38{mu}g/mL$, $66.01{pm}22.04{mu}g/mL$, respectively) and aldehyde ($5.72{pm}0.47{mu}g/mL$, $6.72{pm}1.70{mu}g/mL$, respectively) concentrations in blood compared to those in the alcohol-water group ($199.75{pm}33.83{mu}g/mL$, $50.43{pm}13.88{mu}g/mL$, respectively) at 90 min post-administration. Based on cDNA microarray analysis, expressions of ALDH genes ALDH1a7 and ALDH18a1 and cytochrome P450 (CY450) gene CYP4a30b were upregulated in the alcohol-GB and alcohol-SGB groups compared to levels in the control group. Overall, the results suggest that both GB and SGB have hangover relieving effects by reducing blood acetaldehyde levels. The molecular mechanisms may involve ALDH activation and upregulated expression of alcohol metabolism-related genes such as ALDH and CYP450. |
| Key Words:
Sanghwang mushroom mycelium, aldehyde concentration, germinated buckwheat, hangover relieving effect, locomotor activity test |
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