A pathological study of spontaneous tumors in SPF Ktc : ICR mice

Son, Hwa-young; Kang, Boo-hyon; Han, Sang-seop; Jun, Moo-hyung; Cho, Sung-whan

Korean Journal of Veterinary Research 1992;32(4):609-627.

Hwa-young Son¹, Boo-hyon Kang², Sang-seop Han², Moo-hyung Jun¹, Sung-whan Cho¹

¹College of Veterinary Medicine, Chungnam National University
²Taxicology Research Center, Korea Research Institute of Chemical Technology

SPF Ktc : ICR 마우스의 자연발생 종양에 대한 병리학적 연구

손화영¹, 강부현², 한상섭², 전무형¹, 조성환¹

¹충남대학교 수의과대학
²한국화학연구소 안전성연구센터

Abstract

The study was carried out to obtain the basic data for types, incidence and histopathological features of the spontaneous tumors of the specific pathogen free (SPF) Ktc : ICR mice bred in a barrier system in Technology Research Center, Korea Research Institute of Chemical Technology. One hundred of the mice consisted of 50 males and 50 females were examined for 18 months. 1. The overall incidence rate of spontaneous tumors was 51(51%) of 100 heads tested. The male mice showed slightly higher incidence(28%) than the female(23%), and the incidence rate and the number of affected organs were increased with the increasing age of mice. 2. The incidence rate of primary tumor was 59(59%) of 100 heads tested, consisted of 30 cases (50.8%) of benign tumors and 29 cases(49.2%) of malignant tumors. Among the malignant tumors twenty cases were metastasized to various organs. 3. In tumor incidence rates by systems and organs, the male mice showed the high incidence rate in the liver (18%), hematopoietic system (16% ) and lung (14%), while the female mice, in the hematopoietic system(18%), lung(12%), liver(8%) and uterus(8%). 4. The tumors showing the particularly low incidence rates (<1.0%) were rhabdomyosarcoma in the skeletal muscle, malignant schwannoma in the peripheral nerve, cortical adenoma in the adrenal gland, transitional cell carcinoma in the urinary bladder, tubular cell adenoma in the kidney and adenoma in the pituitary gland and harderian gland.

Key Words: spontaneous tumor, SPF Ktc : ICR mice, histopathology