Effect of renal ischemia on renal function and excretion of lysine, alanine in the rabbit

Nam, Yun-jeong; Kim, Yong-keun; Kim, Joo-heon

Korean Journal of Veterinary Research 1995;35(4):729-733.

Yun-jeong Nam¹, Yong-keun Kim², Joo-heon Kim¹

¹College of Veterinary Medicine, Gyeongsang National University
²College of Medicine, Pusan National University

신장 허혈이 토끼 신기능과 lysine 및 alanine 배설에 미치는 영향

남윤정¹, 김용근², 김주헌¹

¹경상대학교 수의과대학
²부산대학교 의과대학

Abstract

This study was carried out to determine the effect of renal ischemia on renal function and excretion of amino acid in rabbit. The animal models of renal ischemia induced experimentally by clamping the renal artery for different lengths of time. These results were summarized as follows: 1. Ischemia for 30 or 60 min produced a polyuria which is accompanied by an increase in $Na^+$ excretion. Glomerular filtration rate (GFR) and p-aminohippurate plasma($C_{PAH}$) were not altered by 30 min of ischemia, indicating that transient ischemia results in a marked tubular dysfuction before a reduction in GFR or renal blood flow. 2. Reabsorption of glucose and amino acids such as alanine and lysine was markedly reduced after 30 min of ischemia, and the effect was more pronounced after 60 min of ischemia.

Key Words: renal ischemia, renal function, lysine, alanine