Acute and subacute toxicity of fumonisin B<sub>1</sub> to fingerlings of common carp, Cyprinus carpio

Heo, Gang-joon; Lee, Jin-hee; Lee, Yong-soon; Lim, Yoon-kyu

Korean Journal of Veterinary Research 1995;35(4):809-814.

Acute and subacute toxicity of fumonisin B₁ to fingerlings of common carp, Cyprinus carpio

Gang-joon Heo¹, Jin-hee Lee¹, Yong-soon Lee², Yoon-kyu Lim³

¹College of Veterinary Medicine, Chungbuk National University
²College of Veterinary Medicine, Seoul National University
³Department of Veterinary Medicine, Cheju National University

잉어치어(稚魚)에 대한 곰팡이독(fumonisin B₁)의 급성(急性) 및 아급성독성(亞急性毒性)에 관한 연구

허강준¹, 이진희¹, 이영순², 임윤규³

¹충북대학교 수의과대학 수의학과 어류질병학연구실
²서울대학교 수의과대학
³제주대학교 농과대학 수의학과

Abstract

The acute and subacute toxicity of fumomsin $B_1$ was evaluted in fingerlings of common carp, Cyprinus carpio. Dipping of fish for acute toxicity was performed for a period of 48 hours, and the $TLm_{48h}$ value(median tolerance limit) was more than 1000 ppm in common carp. Severe damages were observed in various organs and among them, clubbing of gill lamella, lytic degeneration and vacuolation of liver cells, and epithelial edema of renal tubules were relatively prominent. The most significant changes were hyperbasophilic foci of liver cells in subacute toxicity test and these can imply the possibility of hepatocarcinogenecity of fumonisin $B_1$.

Key Words: fumonisin $B_1$ toxicity, hyperbasophilic foci, common carp