Korean Journal of Veterinary Research 2009;49(3):253-256.
Acute and subacute toxicity of trichlorfon in guppies (Poecilia reticulata)
Gang-Joon Heo1, Gee-Wook Shin2
1College of Veterinary Medicine, Chungbuk National University
2Bio-Safety Research Institute and College of Veterinary Medicine, Chonbuk National University
The aim of the present study was to determine the acute and subacute potential of trichlorfon in guppies (Poecilia reticulatus). We first defined the 24 h median tolerance limit ($TLm_{24h}$) of the fish to trichlorfon. Guppies were then treated with $TLm_{24h}$ and 1/10 $TLm_{24h}$ trichlorfon concentrations to evaluate if any histological alterations occurred. The $TLm_{24h}$ value of trichlorfon was 11 ppm. This concentration resulted in acute toxicity to the gills and kidneys with edema, hyperplasia of the gill lamellae, and vacuolated degeneration and necrosis of renal tubular cells. In the case of subacute toxicity using a 10-fold dilution of the $TLm_{24h}$ value (1.1 ppm), no behavioral changes, external lesions or histopathological changes were observed. Therefore, safe concentration of trichlorfon might be 1.1 ppm in guppy for controlling parasitic infections.
Key Words: guppy, histopathology, $TLm_{24h}$, toxicity, trichlorfon

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