Korean Journal of Veterinary Research 2004;44(1):83-88.
Expression of galectin-3 in rat brain
Yoo-Kyoung Lee1, Hae Eun Kang2, Hee Jong Woo2
1Korea Food & Drug Administration
2Laboratory of Immunology, College of Veterinary Medicine, Seoul National University
랫트 뇌에서의 galectin-3의 검출
이유경1, 강해은2, 우희종2
1식품의약품 안전청
2서울대학교 수의과대학 면역학교실
Abstract
Galectin family, endogenous ${eta}$-galactoside-binding animal lectins, is known for the role in cell differentiation, morphogenesis, apoptosis and tumorigenesis. Galectin-3, one of family member, has been studied for its role in cell differentiation and tumor metastasis, and for its expression on epithelial cells of colon and mast cells but not in brain. Several reports, however, suggest its expression in brain including as a prion binding protein. In this report we explored possibility of galectin-3 expression in brain tissue. With Western blot and RT-PCR with rat brain tissues, we could detect galectin-3 that was not shown by conventional immunohistochemistry. Our results indicated galectin-3 was expressed in brain, and substantiate the previous report on galecin-3 as a prion-related protein in brain.
Key Words: galectin-3, brain, prion binding protein, RT-PCR


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