Anti-obesity effects of onion juice in high fat diet-induced obese rats

Kang, Won Young; Kim, Mun Yong; Jin, Ju Youn; Yang, Heekyoung; Hong, Hyun Ju; Kim, Dong Geon; Han, Chang-Hoon; Lee, Young Jae

Korean Journal of Veterinary Research 2010;50(1):1-10.

Won Young Kang, Mun Yong Kim, Ju Youn Jin, Heekyoung Yang, Hyun Ju Hong, Dong Geon Kim, Chang-Hoon Han, Young Jae Lee

College of Veterinary Medicine, Jeju National University

비만 유도 흰쥐에 대한 양파의 항비만 효과

강원영, 김문용, 진주연, 양희경, 홍현주, 김동건, 한창훈, 이영재

제주대학교 수의과대학

Abstract

This study investigated the effects of onion juice on the serum lipid components and blood pressure in obese rats fed high fat diets. Thirty-nine of Sprague-Dawley rats were divided into six groups, and were treated for 8 weeks: (1) normal diet (ND); (2) high fat diet (HFD); (3) HFD for first 4 weeks and high fat diet with 40% onion juice for the last 4weeks (H-H+O); (4) HFD with 40% onion juice for 8 weeks (H+O); (5) HFD for first 4 weeks and ND for the last 4 weeks (H-N); (6) HFD for first 4 weeks and ND with 40% onion juice for the last 4 weeks (H-N+O). The rates of increasing body weight were reduced in H+O and H-H+O groups compared with HFD group. The levels of triglyceride, low density lipoprotein-cholesterol and total cholesterol in blood serum were significantly decreased in the H+O and H-H+O groups compared with the HFD group. Administration of onion reduced the size of adipocyte, steatosis, and serum hyperlipidemia in obese rats fed HFD. Moreover, the antihypertensive effects of onion were observed in obesity rat fed HFD. Overall results suggest that onion reduces the serum lipid components and improves hypertension in obese rat fed HFD.

Key Words: high fat diet, hyperlipidemia, hypertension, obesity, onion