| Anti-glycemic effect of L-carnosine in streptozotocin-induced diabetic mice |
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Jin-Joo Hue1, Jong-Soo Kim1, Jun-hyeong Kim1, Sang Yoon Nam1, Young Won Yun1, Jae-Hwang Jeong2, Beom Jun Lee1 |
1College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University
2Department of Biotechnology and Biomedicine, Chungbuk Provincial University of Science and Technology |
| Streptozotocin으로 유도된 당뇨 마우스에서 L-carnosine의 혈당강하 효과 |
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허진주1, 김종수1, 김준형1, 남상윤1, 윤영원1, 정재황2, 이범준1 |
1충북대학교 수의과대학
2충북도립대학 의생명과학과 |
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| Abstract |
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Carnosine is a dipeptide $(eta-alanyl-L-histidine)$ found in mammalian brain, eye, olfactory bulb and skeletal muscle at high concentrations. Its biological functions include antioxidant and anti-glycation activities. The objectives of this study were to investigate anti-diabetic effects of carnosine as determined by blood glucose levels, glucose tolerance test (GTT), glycosylated hemoglobin, and serum biochemical and lipid levels in streptozotocin-induced diabetic mice. There were five experimental groups including normal (ICR mice), control (saline), and three groups of carnosine at doses of 6, 30, and 150 mg/kg b.w.. Carnosine was orally administered to the diabetic mice everyday for 12 weeks. There was no significant difference in body weight changes in carnosine-treated groups compared to the control. The treatments of carnosine at the dose of 6 mg/kg significantly decreased the blood glucose level compared with the control at 2 and 4 weeks. The treatments of carnosine at the doses of 6 and 30 mg/kg significantly decreased the blood glucose levels in GTT and glycosylated hemoglobin compared with the control. Carnosine significantly increased total proteins compared with the control. Carnosine at the dose of 6 mg/kg significantly decreased total cholesterol and triglyceride in the serum compared to the control. These results suggest that carnosine at a low level has a hypoglycermic effect resulting from reduction of blood glucose and that a carnosine-containing diet or drug may give a benefit for controlling diabetes mellitus in humans. |
| Key Words:
blood glucose, carnosine, diabetes, streptozotocin |
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