Korean Journal of Veterinary Research 2010;50(2):105-111.
Anti-glycemic effect of L-carnosine in streptozotocin-induced diabetic mice
Jin-Joo Hue1, Jong-Soo Kim1, Jun-hyeong Kim1, Sang Yoon Nam1, Young Won Yun1, Jae-Hwang Jeong2, Beom Jun Lee1
1College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University
2Department of Biotechnology and Biomedicine, Chungbuk Provincial University of Science and Technology
Streptozotocin으로 유도된 당뇨 마우스에서 L-carnosine의 혈당강하 효과
허진주1, 김종수1, 김준형1, 남상윤1, 윤영원1, 정재황2, 이범준1
1충북대학교 수의과대학
2충북도립대학 의생명과학과
Abstract
Carnosine is a dipeptide $(eta-alanyl-L-histidine)$ found in mammalian brain, eye, olfactory bulb and skeletal muscle at high concentrations. Its biological functions include antioxidant and anti-glycation activities. The objectives of this study were to investigate anti-diabetic effects of carnosine as determined by blood glucose levels, glucose tolerance test (GTT), glycosylated hemoglobin, and serum biochemical and lipid levels in streptozotocin-induced diabetic mice. There were five experimental groups including normal (ICR mice), control (saline), and three groups of carnosine at doses of 6, 30, and 150 mg/kg b.w.. Carnosine was orally administered to the diabetic mice everyday for 12 weeks. There was no significant difference in body weight changes in carnosine-treated groups compared to the control. The treatments of carnosine at the dose of 6 mg/kg significantly decreased the blood glucose level compared with the control at 2 and 4 weeks. The treatments of carnosine at the doses of 6 and 30 mg/kg significantly decreased the blood glucose levels in GTT and glycosylated hemoglobin compared with the control. Carnosine significantly increased total proteins compared with the control. Carnosine at the dose of 6 mg/kg significantly decreased total cholesterol and triglyceride in the serum compared to the control. These results suggest that carnosine at a low level has a hypoglycermic effect resulting from reduction of blood glucose and that a carnosine-containing diet or drug may give a benefit for controlling diabetes mellitus in humans.
Key Words: blood glucose, carnosine, diabetes, streptozotocin


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