Korean J Vet Res > Volume 54(2); 2014 > Article
Korean Journal of Veterinary Research 2014;54(2):75-79.
DOI: https://doi.org/10.14405/kjvr.2014.54.2.75    Published online June 30, 2014.
Evaluation of the immunogenicity of Bordetella bronchiseptica, a vaccine antigen
Su-Han Woo, Sun-Young Moon, Yun-Young Byon, Hong-Gu Joo
Laboratory of Veterinary Pharmacology, College of Veterinary Medicine, Jeju National University
Bordetella bronchiseptica 백신항원의 면역원성 평가
우수한, 문선영, 변윤영, 주홍구
제주대학교 수의과대학 수의약리학실
Bordetella (B.) bronchiseptica is a causative agent of swine atrophic rhinitis that promotes colonization of the mucous membrane of the swine nasal cavity by Pasteurella (P.) multocida. Mixed infection with B. bronchiseptica and P. multocida leads to growth inhibition of pigs, resulting in significant economic loss. There are many commercial vaccines for atrophic rhinitis, including B. bronchiseptica as a killed vaccine antigen (Ag). However, the immunogenicity of killed B. bronchiseptica Ag has not yet been elucidated; therefore, this study was conducted to investigate the immunogenicity of killed B. bronchiseptica Ag and the type of immune response it induces. In vitro assays using mouse spleen cells and flow cytometry revealed that B. bronchiseptica Ag induced high proliferation capability of lymphocytes, especially B lymphocytes, and the proliferating cells showed a significant response to interleukin (IL)-2. B. bronchiseptica Ag also enhanced the production of IL-12, a representative cytokine for cell-mediated immunity. In vivo experiments using mice showed that the injection of B. bronchiseptica Ag markedly induced Ag-specific antibody. Taken together, these results indicate that B. bronchiseptica Ag has high immunogenicity by itself.
Key Words: Bordetella bronchiseptica, immunogenicity, spleen cells

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