Korean J Vet Res > Volume 59(2); 2019 > Article
Korean Journal of Veterinary Research 2019;59(2):89-96.
DOI: https://doi.org/10.14405/kjvr.2019.59.2.89    Published online July 15, 2019.
Prevalence and molecular characterization of novel recombinant enterovirus G isolates in Jeju Province of South Korea
Ji Hyun Jeon, Changhee Lee
Animal Virology Laboratory, School of Life Sciences, BK21 Plus KNU Creative BioResearch Group, Kyungpook National University
Correspondence:  Changhee Lee, Tel: 82-53-950-7365, Fax: 82-53-955-5522, 
Email: changhee@knu.ac.kr
Abstract
Enterovirus species G (EV-G) is highly diverse, and is ubiquitous in pig populations, usually without diarrhea. The present study aimed to investigate the presence of novel EV-G recombinants with the torovirus papain-like cysteine protease (PLCP) in Jeju pig herds. EV-G1-PLCP mono-infections were most prevalent in diarrheic weaned piglets. The PLCP genes of the Jeju isolates varied in size and junction sequences, and were greatly heterogeneous, with 77.0-90.7% homology amongst all recombinants. Our results suggest that the exogenous PLCP gene has undergone continuous rapid mutation in the individual EV-G genomes following cross-order recombination, thereby causing clinical disease in swine.
Key Words: cross-order recombination, EV-G, PLCP, porcine diarrhea, torovirus


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