Effects of histamine on the ruminal smooth muscle motility of cattle

Yoon, Byeong-cheol; Han, Ho-jae; Han, Bang-keun

Korean Journal of Veterinary Research 1994;34(3):471-478.

Byeong-cheol Yoon, Ho-jae Han, Bang-keun Han

College of Veterinary Medicine, Chonnam National University

소(牛)의 제1위 평활근 운동성에 대한 histamine의 효과

윤병철, 한호재, 한방근

전남대학교 수의과대학 생리학교실

Abstract

Effects of histamine on the ruminal smooth muscle motility of cattle were investigated in the longitudinal and circular smooth muscle strips. In order to these experiments, specimens were obtained from 35 korean native cattles, 3-4 years old, in Kwang-ju area slaughterhouse. Smooth muscle strips of rumen were made from sample, and then measured the isometric contraction with physiograph in $37{^{circ}C}$ organ bath. The results were as follows : 1. Histamine caused two different types of response(a contraction or a relaxation) on the smooth muscle of cattle rumen. These responses increased in dose dependant manner. 2. Pyrilamine($H_1$-receptor antagonist) completely blocked contraction in all the preparation and converted the response into relaxation. 3. Cimetidine($H_2$-receptor antagonist) completely blocked relaxation in all the preparation and converted the response into contraction. 4. The contraction induced by histamine($10^{-3}M$) was not Mocked by cholinergic, adrenergic blocker or hexamethonium. 5. The contraction induced by histamine($10^{-3}M$) was markedly inhibited in the $Ca^{2+}$ free(or EDTA 2Na) Kreb's solution and by verapamil.

Key Words: rumen, smooth muscle, motility, histamine