| Effect of carboxymethyl chitosan on postoperative intraperitoneal adhesion formation in the rat |
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Kwang-ho Jang, Yong-sam Kwon, Jung-eun Kim, Eun-ju Kwon, Tae-ho Oh, Keun-woo Lee, In-ho Jang |
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College of Veterinary Medicine, Kyungpook National University |
| Rat에서 carboxymethyl chitosan의 복강수술후 유착형성에 미치는 효과 |
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장광호, 권영삼, 김정은, 권은주, 오태호, 이근우, 장인호 |
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경북대학교 수의과대학 |
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| Abstract |
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The aim of this study was to determine the effectiveness of carboxymethyl chitosan(CMC) solution on preventing intraperitoneal adhesions. In this study, 44 rats were divided into four groups ; an untreated control group and three experimental groups that were treated with 3 ml of 1, 2 or 3% CMC solution, respectively. The anti-mesenteric serosa of the ileum was exteriorized and then abraded in a standard manner by scraping with a scalpel blade to create homogenous petechial hemorrhagic surface over a $0.5{ imes}1cm$ area. The adhesions were blindly assessed 2 weeks later by using a computerized tensiometer. The mean tensile strength(Newton) of formed adhesions was $2.48{pm}0.88$ in control group, $1.86{pm}0.56$ in the 1% CMC-treated group, $1.75{pm}0.71$ in the 2% CMC-treated group and $1.55{pm}0.60$ in the 3% CMC-treated group. The most favorable prevention against adhesion was achieved in the 3% CMC-treated group(p<0.01). We could conclude that CMC was effective on preventing the formation of postoperative small intestinal adhesions in the rat. |
| Key Words:
carboxymethyl chitosan, intraperitoneal adhesion, rat, tensile strength |
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